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Immunology explores how organisms defend against infections. Without immune defenses, humans and animals would face severe threats from bacterial, viral, fungal, or parasitic invasions. Vaccinology focuses on creating vaccines to stimulate protective immune responses. The University of Liverpool's Institute of Infection, Veterinary, and Ecological Sciences (IVES) unites top medical, veterinary, and scientific researchers from the Faculty of Health and Life Sciences. We stand among the rare UK academic institutions that have developed, produced, and evaluated a human vaccine through clinical trials. Our extensive human sample repository supports immunological studies, enhancing vaccine effectiveness and guiding future innovations. Immunology and Vaccinology research operates across four modern facilities: the Biosciences Building, IC2, Leahurst campus, and Ronald Ross Building. The Centre for Global Vaccine Research collaborates across Europe, Asia, Africa, and South America. Our work covers the entire vaccine spectrum, from creation to real-world application and assessment. The research examines cellular and antibody-based immune reactions to pathogens affecting humans and animals. Studies focus on immune responses and vaccination strategies for various threats, including: SARS-CoV-2, influenza, Salmonella, Streptococcus pneumoniae, chicken metapneumovirus, Cryptosporidium, cytomegalovirus and other herpesviruses, cyathostomins, Fasciola, Giardia, HIV, Japanese encephalitis virus, Mycobacterium tuberculosis, Neospora caninum, Onchocerca, Toxoplasma, Leptospira, Treponema, and Zika virus.