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Our dedication to Critical Care addresses severe conditions like Sepsis and Trauma, which rank among the top global mortality factors and present ongoing healthcare obstacles for the NHS, particularly in emergency departments and intensive care units. The University of Liverpool's Institute of Infection and Global Health was founded to unite top medical, veterinary, and fundamental science researchers from throughout the Faculty of Health and Life Sciences. It synergizes with other Liverpool-based institutions such as the Liverpool School of Tropical Medicine, the Wolfson Centre for Personalised Medicine, the Medicines for Children Research Network, and the Wellcome Trust Tropical Centre, including its affiliated PhD program.
Critical care research requires comprehension of intricate biological processes triggered by acute cellular damage, whether from infection, trauma, or ischemic events like thrombosis. These mechanisms involve a complex interaction between the initial injury and the body's defensive reaction, which starts as protective but can become harmful if overly intense or uncontrolled, potentially leading to fatal outcomes. These processes intertwine coagulation, inflammation, and innate immunity in varying proportions and at different stages.
At IGH, our research prioritizes detecting molecular indicators that signal critical transitional phases during severe illness, particularly early signs of harmful physiological responses. These findings could lead to improved diagnostic methods, enabling clinicians to identify optimal intervention moments. Parallel to this is the pursuit of innovative treatments for critically ill patients, with a particular focus on creating new therapies guided by biomarker discoveries.