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Chemical biology applies chemical concepts to investigate and modify biological processes while utilizing biological systems to progress chemical research. It combines methodologies from diverse scientific disciplines to drive breakthroughs at the intersection of chemistry, biology, and medicine. The University of Maryland's Department of Chemistry and Biochemistry demonstrates particular expertise in chemical biology, with faculty research spanning crucial topics where chemistry and biology meet. Key areas of investigation encompass: molecular recognition through self-assembly and host-guest systems, creating innovative molecular probes to understand biological mechanisms, specialized analytical techniques for enzyme reaction studies, novel methods for examining posttranslational modifications like ubiquitination and glycosylation, targeted antibody therapeutics modification, biopolymer structure and biophysical chemistry analysis, sophisticated computational modeling of biological systems, functional proteomics and glycomics research, plus nanotechnology applications for drug delivery and vaccine design.