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The Department of Molecular Biosciences and Bioengineering (MBBE) was formed in 1999 through a restructuring of the College of Tropical Agriculture and Human Resources (CTAHR). The majority of MBBE faculty originated from three previous CTAHR departments: Plant Molecular Physiology (PMP), Environmental Biochemistry, and Biosystems Engineering. At that time, only PMP maintained an active graduate program providing both doctoral and master's degrees. Initiated in 1985, the PMP Graduate Program primarily focused on plant biology and biotechnological research.
Following MBBE's creation, the PMP Graduate Program underwent restructuring, broadening its scope and becoming the MBBE Graduate Program in 2000. The curriculum expanded to encompass molecular biology, biochemistry, bioinformatics, cellular biology, biotechnological applications, and engineering principles related to plant sciences, tropical agriculture, marine cultivation, environmental cleanup, bioprocessing, and medical sciences.
This academic expansion invited participation from faculty and researchers across other University of Hawaii departments and Hawaiian research institutions, who joined as affiliated graduate faculty. Student enrollment grew accordingly. Comprehensive standards and requirements were implemented to uphold rigorous academic quality, with periodic reviews ensuring curriculum relevance across disciplines. Today, numerous MBBE graduate students receive guidance from faculty at various institutions including the John A. Burns School of Medicine, Cancer Research Center, Pacific Biomedical Research Center, Queens Medical Center, Hawaii Agricultural Research Center, Sea Grant College Program, School of Ocean and Earth Science and Technology, College of Engineering, and multiple departments spanning Microbiology, Zoology, Human Nutrition, Food and Animal Sciences, and Plant and Environmental Protection Sciences. Consequently, MBBE evolved into an interdisciplinary graduate program anchored in molecular biosciences while incorporating tropical agriculture, biological/medical sciences, and engineering disciplines.