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Immunology explores the complex molecules that distinguish an organism's own cells from its beneficial microbes and external surroundings, the cellular mechanisms programmed to identify and react to threats, and how these elements influence overall health. While typically viewed as a specialized area of biomedical study, Caltech approaches immunology as an intricate biological network where key players can be understood by observing the system's response to changing conditions. Researchers here concentrate on aspects of immunology that benefit most from interdisciplinary connections, fostering collaborations with developmental biology, structural biology, neurobiology, and microbiology. This unique approach provides Caltech's immunologists with exceptional opportunities to integrate innovative concepts, techniques, and methodologies beyond traditional immunological frameworks.