PhD in Cardiovascular - Molecular Machinery of Muscle Contraction in Leeds United Kingdom | University of Leeds

Pursuing a research degree in the Faculty of Biological Sciences allows you to acquire and enhance skills as an autonomous investigator in your selected discipline. Guided by your principal supervisor and additional co-supervisors, you'll have the opportunity to conduct pioneering research on specific biological challenges while joining an extensive research network that employs interdisciplinary methods to address contemporary scientific inquiries. During your doctoral studies, you'll not only deepen your expertise in your specialized area but also cultivate abilities through structured training initiatives and participation in academic seminars and conferences.

The contraction process in cardiac and skeletal muscles relies on the exact organization and interplay of excitation-contraction components and their regulatory signaling pathways. Our investigations utilize various imaging and biochemical techniques to examine the molecular mechanisms behind striated muscle contraction, with special emphasis on proteins governing intracellular calcium levels. We ultimately apply multi-scale computational modeling to connect super-resolution imaging findings with cellular and organ-level performance, analyzing how protein expression patterns and spatial distribution influence both normal and impaired cardiac activity.