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Access to safe and wholesome food is essential for human survival. Food safety risks arise from microbial and chemical pollutants that may lead to acute illness or long-term health conditions. Various factors including climate change, economic hardship, and political instability can disrupt food availability. Furthermore, both unintentional and intentional food adulteration presents serious health threats, exemplified by incidents like China's melamine-laced milk or the EU's fipronil-contaminated eggs. Our studies tackle these food safety, security, and public health concerns by: Examining health effects of naturally occurring toxins in low- and middle-income countries using biomarker analysis and epidemiological research. Detecting natural food contaminants including mycotoxins and plant-based cyanides. Exploring connections between food safety, nutritional adequacy, and population health. Developing innovative food processing methods to minimize toxins. Improving nutrient absorption and decreasing food loss throughout the supply chain.