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Approximately one-third of all approved medications target G protein-coupled receptors (GPCRs), establishing them as the most effective drug targets ever discovered. Our studies concentrate on GPCR structures, functions, and the signaling mechanisms crucial for various physiological and pathological processes.
Our PhD programs provide comprehensive training in molecular pharmacology, with our renowned international research team specializing in pharmacological studies, cellular signaling, drug development, and utilizing diverse transgenic and disease mouse models to investigate GPCR subtypes' physiological roles and therapeutic potential. As the most abundant cell surface receptor family, GPCRs regulate virtually all cellular responses in mammals. About 30% of approved drugs act on GPCRs, cementing their status as the most productive drug targets in medicine.
We investigate GPCR architecture and functionality while deciphering critical signaling pathways for different biological and disease-related responses. Using diverse interdisciplinary methods, we adopt a comprehensive "molecule-to-behavior" strategy to explore, verify, and transform therapeutic possibilities by targeting both membrane and intracellular signaling routes. We discover distinctive small molecule compounds that influence cellular signaling networks, employing them to uncover fundamental biological mechanisms and their impact on disease development and recovery.