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The Department of Molecular Genetics operates from the Medical Sciences Building, with close to 100 faculty members conducting research across multiple facilities including the Best Institute, Donnelly Centre for Cellular and Biomolecular Research, FitzGerald Building, Hospital for Sick Children, Mount Sinai Hospital, Ontario Institute for Cancer Research, and Princess Margaret Hospital.
The Molecular Genetics graduate programs (MSc and PhD) provide research opportunities across diverse genetic systems, from microorganisms to human subjects. Investigative areas span DNA repair mechanisms, gene regulation, cellular signaling, host-pathogen interactions, developmental genetics in model organisms (such as nematodes, fruit flies, and mice), neurobiology, immunology, cancer biology, structural biology, and therapeutic gene applications.
Researchers in Genetic Models of Development and Disease explore how genomic instructions guide multicellular organism formation, how these processes go awry in diseases like cancer, and how fundamental developmental pathways are conserved across species. The transformation from a single fertilized egg to a complex organism has long captivated scientists. Modern genetic and molecular techniques have uncovered key mechanisms governing body patterning, cell specialization, and organ formation. Notably, studies reveal that a core set of regulatory pathways operates universally across species, controlling cell fate decisions, tissue growth, and morphological development. This evolutionary conservation allows insights from simple model organisms to illuminate human development and genetic disorders.