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The Department of Molecular Genetics operates from the Medical Sciences Building, with approximately 100 faculty members conducting research across multiple facilities including the Best Institute, Donnelly Centre for Cellular and Biomolecular Research, FitzGerald Building, Hospital for Sick Children, Mount Sinai Hospital, Ontario Institute for Cancer Research, and Princess Margaret Hospital.
The Molecular Genetics graduate programs (MSc and PhD) provide research opportunities across diverse genetic models, from microorganisms to human systems. Investigative areas encompass DNA processes, gene regulation, cellular communication, host-pathogen interactions, developmental biology in various organisms, neurobiology, immunology, cancer research, structural biology, and human genetic therapies.
Computational Biology utilizes advanced data analysis to decipher complex biological systems, while Systems Biology examines these systems holistically through integrated experimental and computational approaches. These complementary disciplines aim to uncover fundamental cellular mechanisms, disease pathways, and potential treatments. Recent breakthroughs include whole-cell simulations, large-scale genomic analyses for disease mutation mapping, discoveries in RNA processing, protein networks, metabolic pathways, and comprehensive genetic interaction models - all contributing to significant advances in our understanding of biological systems and therapeutic development.