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Recent breakthroughs in AI and computing are allowing systems within our physical surroundings to grow increasingly self-sufficient. Achieving complete autonomy requires three key components: sensing, decision-making, and execution. Smart sensor technologies typically handle perception, while data-informed models provide reliable cognition, and intelligent control systems ensure safe operation. The Mechanical Engineering faculty specializing in Intelligent and Autonomous Systems tackle pioneering challenges across these domains, encompassing multi-physics dynamic modeling, self-sensing capabilities, resilient control systems, data-based diagnostics, smart materials, system optimization, and safety verification. Their work finds applications in robotic monitoring systems, electric vehicles, customized medical solutions, and aerial robotics, with significant implications for sectors like energy, aerospace, healthcare, and mobility.