PhD in Biological Sciences - Structural and Computational Biology and Biophysics in West Lafayette United States | Purdue University

The Structural and Computational Biology and Biophysics Research Area brings together faculty focused on molecular-scale investigations (spanning cellular and subcellular levels). Their work explores diverse subjects including: analyzing protein and nucleic acid architectures, examining the function and structure of protein/RNA enzymes (including cancer-related proteins), membrane biochemistry and protein organization, macromolecular complex formations, viral structures and mechanisms (covering emerging threats like West Nile and Dengue viruses), computational and experimental studies of biomolecular interactions, gene regulation through epigenetic factors like chromosomal and nucleosomal arrangements, plant cell wall and cytoskeletal dynamics, cellular adaptation to high-salinity environments, along with genomics, transcriptomics, proteomics, systematics, computational systems biology, and other experimental-computational intersections. Researchers employ varied methodologies from X-ray crystallography, NMR, cryo-EM, electron tomography, and advanced spectroscopy for molecular analysis to computational approaches for nucleic acid/protein modeling, bioinformatics, genomics, and systems biology – incorporating molecular simulations, machine learning, and network analysis techniques.