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We explore how a single cell develops into a complete organism—insights that enhance our comprehension of health and aging, forming the foundation for novel medical treatments. Our expertise guides cell differentiation for regenerative medicine and disease modeling, especially within the nervous system. Additionally, we study how sensory signals are received and interpreted by the nervous system in both healthy and diseased states, seeking potential targets for gene therapies. The University of Sheffield boasts a distinguished history in developmental biology, neuroscience, stem cell research, and regenerative medicine, earning global recognition in these disciplines. A key societal objective is uncovering why some individuals enjoy prolonged health while others face chronic or degenerative diseases. Connected to this is the urgency to enhance treatments for those with persistent, debilitating conditions. Our work offers a promising pathway to address these critical challenges.