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This research program consists of multiple interconnected studies supported by diverse funding sources such as the MRC, NIHR, pharmaceutical firms, and charitable organizations. Over the past twenty years, economic assessments have become more prevalent in guiding healthcare resource distribution globally (for example, through NICE). A fundamental challenge in economic evaluation involves how healthcare benefits are quantified and assessed. One prevalent approach is cost-effectiveness analysis employing Quality Adjusted Life Years (QALYs), which enables comparison of effectiveness across different healthcare treatments. Standard techniques for determining the 'quality' component of QALYs include generic health measurement tools like the EQ-5D, SF-6D, HUI2, and HUI3. Health authorities like NICE frequently utilize these standardized measures to analyze intervention cost-effectiveness in their models.