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Approximately one-third of all approved medications target G protein-coupled receptors (GPCRs), establishing them as the most effective drug targets to date. Our studies concentrate on GPCR structures, functions, and the signaling mechanisms crucial for various physiological and pathological processes.
Our PhD programs provide comprehensive training in molecular pharmacology, with our renowned international research team specializing in pharmacological studies, cellular signaling, drug development, and utilizing diverse transgenic and disease mouse models to investigate GPCR subtypes' physiological roles and therapeutic possibilities. As the most abundant cell surface receptor family, GPCRs control virtually all cellular activities in mammals. With about 30% of approved drugs acting on GPCRs, they represent the most productive drug targets in medical history.
We investigate GPCR architecture and functionality while exploring critical signaling pathways for different normal and abnormal biological responses. Using diverse interdisciplinary methods, we adopt a comprehensive "molecule-to-behavior" strategy to discover, verify, and implement therapeutic approaches by targeting both membrane and intracellular signaling routes. We discover distinctive small molecule compounds that influence cellular signaling networks, employing them to uncover fundamental biological mechanisms and their impact on disease development and recovery.