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The Department of Molecular Genetics operates from the Medical Sciences Building, with close to 100 faculty members conducting research across multiple facilities including the Best Institute, Donnelly Centre for Cellular and Biomolecular Research, FitzGerald Building, Hospital for Sick Children, Mount Sinai Hospital, Ontario Institute for Cancer Research, and Princess Margaret Hospital.
Our Master of Science and PhD programs in Molecular Genetics provide research opportunities across diverse genetic systems, from microorganisms to human subjects. Investigative areas encompass DNA repair mechanisms, gene expression regulation, developmental genetics in model organisms, molecular neurobiology, cancer biology, structural biology, and cutting-edge applications in human genetics and gene therapy.
We stand at the threshold of a transformative period in medicine, driven by groundbreaking progress in genetics and genomics. Following the Human Genome Project's revelations, sequencing technologies have evolved dramatically, enabling rapid, cost-effective individual genome analysis. Next-generation sequencing has revolutionized our capacity for genetic diagnosis, risk assessment, and personalized treatment strategies. Department researchers have pioneered discoveries of disease-causing genes for conditions like cystic fibrosis and neurofibromatosis, and now lead investigations into complex disorders including autism, cardiovascular diseases, and various cancers. These advancements are creating pathways for improved diagnostics, targeted therapies, and preventive approaches in human health.