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Addressing critical biological challenges involves applying core chemical concepts. Understanding biosynthetic routes, uncovering new natural compounds, and investigating enzymatic processes inform approaches for medical interventions. Purposeful creation of biologically active substances facilitates the advancement of innovative pharmaceutical agents. Utilizing microscopic and spectroscopic techniques to examine biological macromolecules yields crucial understanding of vital structure-activity connections that regulate living systems. Developing novel probes, detection approaches, and diagnostic tools can produce important resources for tracking and combating illnesses. Our Department's work in these fields is driving the development of medications, delivery systems, imaging compounds, and technologies to diagnose and treat infections, cancers, metabolic disorders, and various other conditions.